abstract：:This prospective study examined the effect of medication compliance and substance abuse on 4 year outcome in 99 patients following a relapse of schizophrenia. Univariate survival analysis revealed longer community tenure in patients if they were over the age of 35 years, not admitted 2 years prior to the index episode...

journal_title：Schizophrenia research

authors： Hunt GE,Bergen J,Bashir M

更新日期：2002-04-01 00:00:00

abstract：:Schizotypy is usually referred to as a "liability" to schizophrenia, but it could also be more generally referred to as nonspecific "psychosis-proneness". This study examined the structure of schizotypy in a normal sample and in a sample of schizophrenics through the administration of the Schizotypal Personality Quest...

journal_title：Schizophrenia research

authors： Rossi A,Daneluzzo E

更新日期：2002-03-01 00:00:00

abstract：:Schizotypal personality disorder, a diagnosis defined partially in terms of a genetic relatedness to schizophrenia, has begun to receive extensive investigative study. While the exact etiologic relationship between schizotypal personality disorder and schizophrenia remains to be determined, three models have been cons...

journal_title：Schizophrenia research

authors： Siever LJ,Koenigsberg HW,Harvey P,Mitropoulou V,Laruelle M,Abi-Dargham A,Goodman M,Buchsbaum M

更新日期：2002-03-01 00:00:00

abstract：:We found previously that a subgroup of schizophrenic patients who passed screening tests of attentional competence showed memory deficits on word memory tasks, but were comparable with controls on tone memory tasks. To better understand the nature of language-specific memory deficits in this subgroup of patients, the ...

journal_title：Schizophrenia research

authors： Wexler BE,Donegan N,Stevens AA,Jacob SA

更新日期：2002-01-15 00:00:00

abstract：:This study tests the hypothesis that deficits of spatial working memory are an inherent trait in schizophrenic patients, regardless of their clinical status. The participants were 22 chronic schizophrenic patients, 11 schizophrenic patients in remission, and 22 normal adults. All participants were asked to track the o...

journal_title：Schizophrenia research

authors： Okada A

更新日期：2002-01-01 00:00:00

abstract：:Since the recognition that adults with velocardiofacial syndrome (VCFS), which is associated with hemizygous interstitial deletions of chromosome 22q11, frequently show psychotic symptoms, deletion of the 22q11.2 region has been proposed as a common genetic abnormality associated with schizophrenia. In studies of schi...

journal_title：Schizophrenia research

authors： Arinami T,Ohtsuki T,Takase K,Shimizu H,Yoshikawa T,Horigome H,Nakayama J,Toru M

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Appropriate expression of emotions and correct perception of emotional expression in others are important social skills which may be impaired in schizophrenia and contribute to poor social adjustment. We examined the relationship between expression of emotions as measured by affective flattening and other ne...

journal_title：Schizophrenia research

authors： Silver H,Shlomo N

更新日期：2001-12-01 00:00:00

abstract：:Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...

journal_title：Schizophrenia research

authors： Wood SJ,Velakoulis D,Smith DJ,Bond D,Stuart GW,McGorry PD,Brewer WJ,Bridle N,Eritaia J,Desmond P,Singh B,Copolov D,Pantelis C

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVES:Recent reports of antibodies to heat shock proteins 60kDa (HSP60) and HSP70 suggested that antibodies to the heat shock protein that plays a protective role against environmental stresses in a cell might be related to the pathogenesis of schizophrenia, although the antibody to HSP90 had not yet been identifi...

journal_title：Schizophrenia research

authors： Kim JJ,Lee SJ,Toh KY,Lee CU,Lee C,Paik IH

更新日期：2001-10-01 00:00:00

abstract：:Research on the effectiveness of treatment programs in early stages of severe mental illness raise significant ethical questions when conducted in industrialized countries that have adequate protections for the human subjects of biomedical and behavioral research. Before embarking on similar trials in developing count...

journal_title：Schizophrenia research

authors： Macklin R

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:The normal vasodilatory response to ingestion of nicotinic acid (NA) is impaired in some patients with schizophrenia. It is unclear whether the impairment is a feature of the disorder itself or to a confounding factor such as neuroleptics, caffeine or nicotine use. METHODS:To address this question in a cont...

journal_title：Schizophrenia research

authors： Turenne SD,Seeman M,Ross BM

更新日期：2001-07-01 00:00:00

abstract：:Auditory--verbal hallucinations (AVH) are a characteristic feature of schizophrenia. Patients with AVHs have been found to differ from non-hallucinating patients in volumes of certain asymmetrical brain structures on MRI, and on certain neuropsychological measures. There is also evidence of corpus callosum (CC) abnorm...

journal_title：Schizophrenia research

authors： Rossell SL,Shapleske J,Fukuda R,Woodruff PW,Simmons A,David AS

更新日期：2001-05-30 00:00:00

abstract：:Many children of a schizophrenic parent may inherit a portion of the genetic risk factors for schizophrenia. The frequency of DSM-IV psychopathology in children of a schizophrenic parent and the frequency and type of mental health treatment accessed by these youths is not well understood. Twenty-eight adults with schi...

journal_title：Schizophrenia research

authors： Ross RG,Compagnon N

更新日期：2001-05-30 00:00:00

abstract：:In response to previous reports of geographical clustering of individuals with psychosis, a study was carried out in Denmark utilizing the national case register. Two-thousand one-hundred and ninety-nine (2199) individuals with schizophrenia were divided by place of birth into 217 geographical areas and analyzed by ag...

journal_title：Schizophrenia research

authors： Torrey EF,Mortensen PB,Pedersen CB,Wohlfahrt J,Melbye M

更新日期：2001-04-30 00:00:00

abstract：:Functional abnormalities in the interhemispheric transfer via the corpus callosum in schizophrenia may result in filtering problems and information processing problems, which may in turn be related to the synchronization of cortical event-related activity. To explore whether a relationship exists between corpus callos...

journal_title：Schizophrenia research

authors： Frodl T,Meisenzahl EM,Müller D,Greiner J,Juckel G,Leinsinger G,Hahn H,Möller HJ,Hegerl U

更新日期：2001-04-15 00:00:00

abstract：:Increased sulcal widening in the prefrontal cortex of patients with schizophrenia may be associated with a poor treatment response to clozapine. To further evaluate this, we examined data from patients treated with clozapine in our center. Patients with the greatest degree of improvement (n=26) and those with no impro...

journal_title：Schizophrenia research

authors： Konicki PE,Kwon KY,Steele V,White J,Fuller M,Jurjus GJ,Jaskiw GE

更新日期：2001-03-30 00:00:00

abstract：:The performance of chronic schizophrenic probands (n=21), their first-degree schizotypal (22) and non-schizotypal (19) relatives, and normal controls (24), was measured in two associative learning paradigms, latent inhibition and the Kamin blocking effect. These paradigms assess the effects on learning of initial expo...

journal_title：Schizophrenia research

authors： Martins Serra A,Jones SH,Toone B,Gray JA

更新日期：2001-03-30 00:00:00

abstract：:The aim of the present study is to explore the relationship between depression and psychotic symptoms of schizophrenia over the course of illness. Sixty-eight patients meeting DSM-IV criteria for schizophrenia were enrolled, 27 in an acute episode, 41 when stable. Assessments were performed using the Calgary Depressio...

journal_title：Schizophrenia research

authors： Lançon C,Auquier P,Reine G,Bernard D,Addington D

更新日期：2001-03-01 00:00:00

abstract：:Genetic epidemiological studies have demonstrated markedly reduced rates in reproduction among schizophrenic patients. According to evolutionary theory, behavioral and psychological phenotypes are selected based on ecological "fit". Where differential survival or reproductive success exists, genotype frequencies are a...

journal_title：Schizophrenia research

authors： Avila M,Thaker G,Adami H

更新日期：2001-03-01 00:00:00

abstract：:The frontal and temporal lobes have been implicated as pathogenic sites for schizophrenia, although there is a marked heterogeneity of brain function and structure between individual patients. It is currently unclear whether some patients with schizophrenia exhibit primarily frontal lobe dysfunction, while others exhi...

journal_title：Schizophrenia research

authors： Allen DN,Goldstein G,Weiner C

更新日期：2001-03-01 00:00:00

abstract：:Estrogen has been shown in animal studies to modulate both the dopamine and serotonin neurotransmitter systems - the main neurotransmitters implicated in the pathogenesis of schizophrenia. A double blind, 28 day, placebo-controlled study was conducted with three groups of women of child-bearing age (N=12 in each group...

journal_title：Schizophrenia research

authors： Kulkarni J,Riedel A,de Castella AR,Fitzgerald PB,Rolfe TJ,Taffe J,Burger H

更新日期：2001-03-01 00:00:00

abstract：:A number of reports of genetic association of human leucocyte antigens (HLA) and alleles with schizophrenia have recently been published. A schizophrenia locus on chromosome 6p near the HLA region has also been reported, on the basis of linkage studies. We have therefore reviewed the investigations of association of H...

journal_title：Schizophrenia research

authors： Wright P,Nimgaonkar VL,Donaldson PT,Murray RM

更新日期：2001-01-15 00:00:00

abstract：BACKGROUND:Because risperidone and olanzapine have similar efficacy and tolerability in the treatment of schizophrenia, costs, physician experience, and preference become relevant considerations in making treatment decisions. The purpose of this paper is to compare daily treatment costs of risperidone and olanzapine, a...

journal_title：Schizophrenia research

authors： Rabinowitz J,Lichtenberg P,Kaplan Z

更新日期：2000-12-15 00:00:00

abstract：:There is some evidence that memory for temporal order is a process that may be impaired independently of other forms of memory. For example, patients with Korsakoff's syndrome have been shown to have poorer temporal-order memory than other amnesic patients, despite item memory being equivalent. Patients with schizophr...

journal_title：Schizophrenia research

authors： Elvevåg B,Egan MF,Goldberg TE

更新日期：2000-12-15 00:00:00

abstract：:This study reports findings of the Edinburgh High Risk Study four years after it began. This study is designed to explore the pathogenesis of schizophrenia by examining a large sample of young adults aged 16-25 years who are at enhanced risk of developing schizophrenia by having two close relatives with the disorder, ...

journal_title：Schizophrenia research

authors： Johnstone EC,Abukmeil SS,Byrne M,Clafferty R,Grant E,Hodges A,Lawrie SM,Owens DG

更新日期：2000-11-30 00:00:00

abstract：:Non-compliance problems may rise to 50% among patients undergoing neuroleptic treatment. There are no direct measures available to predict compliance, if previous non-compliance is not taken into account. Attitudes towards neuroleptic treatment and insight into psychotic symptoms may vary during the course of the trea...

journal_title：Schizophrenia research

authors： Kampman O,Lehtinen K,Lassila V,Leinonen E,Poutanen O,Koivisto A

更新日期：2000-10-27 00:00:00

abstract：OBJECTIVE:This study sought to evaluate levels of insight and change in insight in subjects with schizophrenia and other major psychiatric disorders. This study also evaluated the relationship of insight to acute psychopathology. METHOD:One-hundred and eighty-seven subjects consecutively admitted to an acute care psyc...

journal_title：Schizophrenia research

authors： Weiler MA,Fleisher MH,McArthur-Campbell D

更新日期：2000-09-29 00:00:00

abstract：:This study documents a severe picture naming impairment in a series of 22 chronically hospitalised schizophrenics. The pattern and level of naming impairment were comparable in degree and type to that seen neurological patients with left hemisphere lesions. This deficit was further examined to determine whether it con...

journal_title：Schizophrenia research

authors： Laws KR,Al-Uzri M,Mortimer AM

更新日期：2000-09-29 00:00:00

abstract：:Serum prolactin (PRL) was correlated with clinical symptomatology in 17 drug-free patients suffering from non-affective psychoses. A clear-cut negative correlation was found between the Comprehensive Psychiatric Rating Scale (CPRS) items assessing hallucinations and serum PRL levels (r=-6.14, P=0.009). No correlation ...

journal_title：Schizophrenia research

authors： Appleberg B,Katila H,Rimón R

更新日期：2000-09-01 00:00:00

abstract：:To investigate relationships between birth season and biological family history in schizophrenia, this study used a sample of schizophrenics that had the advantages of (a) particularly thorough diagnostic assessments of schizophrenics' relatives, including information from direct interviews as well as chart reviews, a...

journal_title：Schizophrenia research

authors： Kinney DK,Jacobsen B,Jansson L,Faber B,Tramer SJ,Suozzo M

更新日期：2000-08-03 00:00:00

abstract：:[(3)H]ketanserin binding to 5HT(2A) receptors was measured in the left planum temporale (sensory speech cortex) from schizophrenic and non-schizophrenic (control) subjects using both particulate membranes and tissue sections. There was a significant decrease in the affinity of [(3)H]ketanserin binding to particulate m...

journal_title：Schizophrenia research

authors： Pralong D,Tomaskovic-Crook E,Opeskin K,Copolov D,Dean B

更新日期：2000-07-07 00:00:00

abstract：BACKGROUND:Epidemiologic evidence as early as the 1930s has suggested urbanization is linked to schizophrenia, either by place of admission, place of upbringing, or, more recently, place of birth. In the past decade, obstetric complications have been implicated in the etiology of schizophrenia. METHODS:With appropriat...

journal_title：Schizophrenia research

authors： Eaton WW,Mortensen PB,Frydenberg M

更新日期：2000-06-16 00:00:00

abstract：:Long-stay patients constitute a small proportion of all patients with schizophrenia, but in both VA and state psychiatric systems these patients account for a majority of the costs associated with treatment of the illness. VA and state patients would be expected to differ in several respects, including age at onset an...

journal_title：Schizophrenia research

authors： Harvey PD,Jacobsen H,Mancini D,Parrella M,White L,Haroutunian V,Davis KL

更新日期：2000-05-25 00:00:00

abstract：:In 200 inpatients on regular neuroleptics, point prevalence of extrapyramidal syndromes, including Parkinson syndrome, akathisia and tardive dyskinesia (TD), was studied and found to be 20, 11 and 22%, respectively. A total of 46 patients have currently, and for a longer time, (average about 3years, median over 1year)...

journal_title：Schizophrenia research

authors： Modestin J,Stephan PL,Erni T,Umari T

更新日期：2000-05-05 00:00:00

abstract：:Adolescents meeting diagnostic criteria for schizotypal personality disorder (SPD) are presumed to be at risk for developing schizophrenia in adulthood, making them an important group for exploring the developmental trajectory of the disease. Deficits in executive functioning have been documented in schizophrenia pati...

journal_title：Schizophrenia research

authors： Diforio D,Walker EF,Kestler LP

更新日期：2000-04-07 00:00:00

abstract：:Although patients with schizophrenia have reduced brain size, there is no conclusive evidence that they have reduced head size. This begs the question: 'What is the precise relationship between head size and brain size?' We used a unique osteological collection to explore the relationship between external head measure...

journal_title：Schizophrenia research

authors： Friedman L,Wiechers IR,Cerny CA,Schulz SC,Buckley P

更新日期：2000-03-16 00:00:00

abstract：:The memory profile of acute and chronic schizophrenic patients was examined according to the information processing model, with which encoding, retention and retrieval processes of these patients were compared. The effects of an external organizational strategy on their verbal learning and memory were also examined. T...

journal_title：Schizophrenia research

authors： Chan AS,Kwok IC,Chiu H,Lam L,Pang A,Chow LY

更新日期：2000-02-14 00:00:00

abstract：:Microtubule associated proteins (MAPs) are central to the development of normal neuronal cytoarchitecture and have been reported to be altered in schizophrenia. In 12 schizophrenic (DSM-III-R criteria) and 12 control hippocampi, we estimated the MAP2 immunoreactive dendritic length using antibodies that recognize tota...

journal_title：Schizophrenia research

authors： Cotter D,Wilson S,Roberts E,Kerwin R,Everall IP

更新日期：2000-01-21 00:00:00

abstract：BACKGROUND:cortical gray matter volume deficit and ventricular enlargement are well documented in schizophrenia, but their presence in bipolar disorder is less well established. METHODS:global cortical gray matter, white matter and sulcal CSF, as well as lateral and third ventricular volume measures, were derived from...

journal_title：Schizophrenia research

authors： Lim KO,Rosenbloom MJ,Faustman WO,Sullivan EV,Pfefferbaum A

更新日期：1999-12-21 00:00:00

abstract：:Three-channel actometry was used to study neuroleptic-induced akathisia (NIA), a common and often serious disorder in association of traditional neuroleptic therapy. The aim was to explore the diagnostic possibilities of actometry in NIA and to examine in detail the motor phenomenology of the disorder in detail. The a...

journal_title：Schizophrenia research

authors： Tuisku K,Lauerma H,Holi M,Markkula J,Rimon R

更新日期：1999-11-30 00:00:00